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In vivo functional brain mapping in a conditional mouse

Tauopathies are characterized by intracellular deposition of the microtubule associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally ees mutant human tau protein in various forebrain areas under the Tet off eion system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age.

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